Pathophysiology and genetics of salt-sensitive hypertension

D Maaliki, MM Itani, HA Itani - Frontiers in Physiology, 2022 - frontiersin.org
Most hypertensive cases are primary and heavily associated with modifiable risk factors like
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …

Control of mesenchymal stem cell biology by histone modifications

J Ren, D Huang, R Li, W Wang, C Zhou - Cell & bioscience, 2020 - Springer
Mesenchymal stem cells (MSCs) are considered the most promising seed cells for
regenerative medicine because of their considerable therapeutic properties and …

Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

VC Ghattargi, MA Gaikwad, BS Meti, YS Nimonkar… - BMC genomics, 2018 - Springer
Background Enterococcus faecium though commensal in the human gut, few strains provide
a beneficial effect to humans as probiotics while few are responsible for the nosocomial …

Extracellular vesicles isolated from mesenchymal stromal cells primed with neurotrophic factors and signaling modifiers as potential therapeutics for …

P Teli, V Kale, A Vaidya - Current Research in Translational Medicine, 2021 - Elsevier
Neurodegenerative diseases are characterized by a progressive and irreversible loss of
neuronal cells leading to cognitive impairments and memory loss. Despite being a powerful …

Valproic acid promotes early neural differentiation in adult mesenchymal stem cells through protein signalling pathways

J Santos, T Hubert, BK Milthorpe - Cells, 2020 - mdpi.com
Regenerative medicine is a rapidly expanding area in research and clinical applications.
Therapies involving the use of small molecule chemicals aim to simplify the creation of …

[HTML][HTML] FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells

CW Huang, SY Lu, TC Huang, BM Huang, HS Sun… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: The formation of adipose-derived stem cells (ASCs) into spheres on a chitosan-
coated microenvironment promoted ASCs differentiation into a mixed population of neural …

Histone deacetylase inhibition-mediated neuronal differentiation via the Wnt signaling pathway in human adipose tissue-derived mesenchymal stem cells

S Jang, HS Jeong - Neuroscience letters, 2018 - Elsevier
Histone deacetylase (HDAC) inhibitors, which have an effect on cell homeostasis, cell cycle
progression, and terminal differentiation, can act to promote self-renewal and enhance …

Revisiting Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients with Glioblastoma—Proteomic Alteration …

AV Krauze, Y Zhao, MC Li, J Shih, W Jiang, E Tasci… - Biomolecules, 2023 - mdpi.com
Background: Glioblastoma (GBM) is the most common brain tumor with an overall survival
(OS) of less than 30% at two years. Valproic acid (VPA) demonstrated survival benefits …

Molecular Mechanisms of Transdifferentiation of Adipose‐Derived Stem Cells into Neural Cells: Current Status and Perspectives

L Luo, DH Hu, JQ Yin, RX Xu - Stem cells international, 2018 - Wiley Online Library
Neurological diseases can severely compromise both physical and psychological health.
Recently, adult mesenchymal stem cell‐(MSC‐) based cell transplantation has become a …

Mesenchymal stromal cells preconditioning: a new strategy to improve neuroprotective properties

G Schepici, A Gugliandolo, E Mazzon - International Journal of Molecular …, 2022 - mdpi.com
Neurological diseases represent one of the main causes of disability in human life.
Consequently, investigating new strategies capable of improving the quality of life in …