Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

The past 10 years have seen the publication of results from several multicentre clinical trials
in primary and systemic sclerosis (SSc)-related Raynaud phenomenon. The publication of …

Abstract Introduction Systemic sclerosis (SSc) is an autoimmune connective tissue disorder
characterized by fibroproliferative vasculopathy, immunological abnormalities and …

The pathogenesis of Raynaud's phenomenon is not fully understood. However, the last 20 yr
have witnessed enormous increases in our understanding of different mechanisms which …

The coagulation and immune systems, two vital systems in the human body, share intimate
connections that fundamentally determine patient health. These systems work together …

Systemic sclerosis, commonly known as scleroderma, is an autoimmune disorder
characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. The exact …

Raynaud's phenomenon is a common clinical disorder for which patients frequently seek the
expertise and care of dermatologists. It is manifested by recurrent vasospasm of the fingers …

Objective Increased signaling by transforming growth factor β (TGFβ) has been implicated in
systemic sclerosis (SSc; scleroderma), a complex disorder of connective tissues …

Objective: To evaluate the coagulative/fibrinolytic cascade and the circulating markers of the
endothelial injury in systemic sclerosis (SSc). Method: Plasma was obtained from 29 …

Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable
mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and …