Chemical modifications on mRNA represent a critical layer of gene expression regulation.
Research in this area has continued to accelerate over the last decade, as more …

Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-
cell communication in which microRNAs (miRNAs) produced and released from one cell are …

Newly made mRNAs are processed and packaged into mature ribonucleoprotein complexes
(mRNPs) and are recognized by the essential transcription–export complex (TREX) for …

Background A critical step in uncovering rules of RNA processing is to study the in vivo
regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation …

Summary Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …

In eukaryotes, the separation of translation from transcription by the nuclear envelope
enables mRNA modifications such as capping, splicing, and polyadenylation. These …

RNA turnover is an integral part of cellular RNA homeostasis and gene expression
regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of …

Abstract N 6-methyladenosine (m6A) is the most abundant internal modification of
eukaryotic mRNA. This modification has previously been shown to alter the export kinetics …

The export of mRNA from nucleus to cytoplasm requires the conserved and essential
transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX …