Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Neuroactive steroids refer to steroids that are capable of regulating neuronal activities.
Neuroactive steroids, synthesized either de novo in the nervous tissue or in the peripheral …

The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a
treatment for women with postpartum depression, and successful trials of a related …

Transient receptor potential (TRP) cation channels are renowned for their ability to sense
diverse chemical stimuli. Still, for many members of this large and heterogeneous protein …

Neurosteroids are powerful modulators of brain function and behavior, yet their dynamics in
the brain have remained elusive. Using in vivo microdialysis in male zebra finches, we found …

When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de
novo in neural tissues, they are more specifically referred to as neurosteroids. These …

Neurosteroids are potent and effective neuromodulators that are synthesized from
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …

Neurosteroids represent a class of endogenous steroids that are synthesized in the brain,
the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor …

By rapidly modulating neuronal excitability, neurosteroids regulate physiological processes,
such as responses to stress and development. Excessive stress affects their biosynthesis …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in
synaptic transmission and plasticity. Both hyper‐and hypo‐activation of NMDARs are …