Biological assay has been based on analysis of all individuals collected from sample
populations. Bulked sample analysis (BSA), which works with selected and pooled …

Abstract The Nobel Prize in Chemistry for 2022 was awarded to the pioneers of Lego-like
'click chemistry': combinatorial chemistry with remarkable modularity and diversity. It has …

There is considerable interest in the use of bioorthogonal covalent chemistry such as “click”
chemistries to label small molecules located on live or fixed cells.[1] Such labeling has been …

Papain-like cysteine proteases (PLCPs) are a large class of proteolytic enzymes associated
with development, immunity, and senescence. Although many properties have been …

Ustilago maydis is a biotrophic pathogen causing maize (Zea mays) smut disease.
Transcriptome profiling of infected maize plants indicated that a gene encoding a putative …

Proteases are important targets for the treatment of human disease. Several protease
inhibitors have failed in clinical trials due to a lack of in vivo specificity, indicating the need …

Activity-based protein profiling (ABPP) is a chemical proteomic technique that enables the
interrogation of protein activity directly within complex proteomes. Given the dominant role of …

RD21-like proteases are ubiquitous, plant-specific papain-like proteases typified by carrying
a C-terminal granulin domain. RD21-like proteases are involved in immunity and associated …

The active proteome dictates plant physiology. Yet, active proteins are difficult to predict
based on transcript or protein levels, because protein activities are regulated post …

Background The herbicides glyphosate (Gly) and imazamox (Imx) inhibit the biosynthesis of
aromatic and branched-chain amino acids, respectively. Although these herbicides inhibit …