Liposomes: Structure, composition, types, and clinical applications

H Nsairat, D Khater, U Sayed, F Odeh, A Al Bawab… - Heliyon, 2022 - cell.com
Liposomes are now considered the most commonly used nanocarriers for various potentially
active hydrophobic and hydrophilic molecules due to their high biocompatibility …

siRNA: Mechanism of action, challenges, and therapeutic approaches

W Alshaer, H Zureigat, A Al Karaki, A Al-Kadash… - European journal of …, 2021 - Elsevier
Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to
become an essential approach in treating a variety of infectious, hemato-oncological …

Biomimetic nanoerythrosome‐coated aptamer–DNA tetrahedron/maytansine conjugates: pH‐responsive and targeted cytotoxicity for HER2‐positive breast cancer

W Ma, Y Yang, J Zhu, W Jia, T Zhang, Z Liu… - Advanced …, 2022 - Wiley Online Library
DNA materials have emerged as potential nanocarriers for targeted cancer therapy to
precisely deliver cargos with specific purposes. The short half‐life and low bioavailability of …

Recent progress in non-native nucleic acid modifications

LK McKenzie, R El-Khoury, JD Thorpe… - Chemical Society …, 2021 - pubs.rsc.org
While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

Detection and beyond: Challenges and advances in aptamer-based biosensors

H Yoo, H Jo, SS Oh - Materials Advances, 2020 - pubs.rsc.org
Beyond traditional needs of biosensors such as high sensitivity and selectivity for analyte
detection, newly emerging requirements including a real-time detection ability and in-field …

Next-generation intelligent MXene-based electrochemical aptasensors for point-of-care cancer diagnostics

A Parihar, A Singhal, N Kumar, R Khan, MA Khan… - Nano-Micro Letters, 2022 - Springer
Delayed diagnosis of cancer using conventional diagnostic modalities needs to be
addressed to reduce the mortality rate of cancer. Recently, 2D nanomaterial-enabled …

Recent progress of SELEX methods for screening nucleic acid aptamers

C Zhu, Z Feng, H Qin, L Chen, M Yan, L Li, F Qu - Talanta, 2024 - Elsevier
Nucleic acid aptamers are oligonucleotide sequences screened by an in vitro methodology
called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Known as …

Self-assembling nucleic acid nanostructures functionalized with aptamers

A Krissanaprasit, CM Key, S Pontula… - Chemical …, 2021 - ACS Publications
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

A perspective on oligonucleotide therapy: Approaches to patient customization

S Thakur, A Sinhari, P Jain, HR Jadhav - Frontiers in Pharmacology, 2022 - frontiersin.org
It is estimated that the human genome encodes 15% of proteins that are considered to be
disease-modifying. Only 2% of these proteins possess a druggable site that the approved …

DNA nanostructures: current challenges and opportunities for cellular delivery

A Lacroix, HF Sleiman - ACS nano, 2021 - ACS Publications
DNA nanotechnology has produced a wide range of self-assembled structures, offering
unmatched possibilities in terms of structural design. Because of their programmable …