Simple Summary Cancer is considered as a large group of diseases involving abnormal cell
growth, which results in an alarming rise in the mortality rate at the worldwide level …

A significant number of drugs and drug candidates in clinical development are halogenated
structures. For a long time, insertion of halogen atoms on hit or lead compounds was …

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …

Aggregation of hyperphosphorylated tau is one of the characteristic neuropathological
lesions of Alzheimer's disease and other neurodegenerative disorders. Pharmacological …

ABSTRACT CDK9 is a protein in constant development in cancer therapy. Herein we
present an overview of the enzyme as a target for cancer therapy. We provide data on its …

Cancer is one of the major causes of death and the number of new cases, as well as the
number of individuals living with cancer, is expanding continuously. Worldwide the alarming …

Cyclin-dependent kinase-2 (CDK2) is a member of protein kinase family. It plays an
important role in regulating various events of eukaryotic cell division cycle. Accumulated …

Despite promising preclinical studies with the cyclin-dependent kinase inhibitor flavopiridol
in chronic lymphocytic leukemia (CLL) and other diseases, previous clinical trials with this …

Unlike other CDKs, CDK9 does not regulate the cell cycle but promotes RNA synthesis in
genetic programmes for cell growth, differentiation and viral pathogenesis. It is becoming …

In a routine screening of our small-molecule compound collection we recently identified 4-
arylazo-3, 5-diamino-1 H-pyrazoles as a novel group of ATP antagonists with moderate …