[HTML][HTML] Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update
Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries
but common in some specific geographical regions of developing countries. Late diagnosis …
but common in some specific geographical regions of developing countries. Late diagnosis …
[HTML][HTML] Gallbladder carcinoma: prognostic factors and therapeutic options
TO Goetze - World journal of gastroenterology, 2015 - ncbi.nlm.nih.gov
The outcome of gallbladder carcinoma is poor, and the overall 5-year survival rate is less
than 5%. In early-stage disease, a 5-year survival rate up to 75% can be achieved if stage …
than 5%. In early-stage disease, a 5-year survival rate up to 75% can be achieved if stage …
P21 activated kinases: structure, regulation, and functions
CK Rane, A Minden - Small GTPases, 2014 - Taylor & Francis
The p21 activated kinases (Paks) are well known effector proteins for the Rho GTPases
Cdc42 and Rac. The Paks contain 6 members, which fall into 2 families of proteins. The first …
Cdc42 and Rac. The Paks contain 6 members, which fall into 2 families of proteins. The first …
Aneuploidy: Cancer strength or vulnerability?
G Simonetti, S Bruno, A Padella, E Tenti… - … journal of cancer, 2019 - Wiley Online Library
Aneuploidy is a very rare and tissue‐specific event in normal conditions, occurring in a low
number of brain and liver cells. Its frequency increases in age‐related disorders and is one …
number of brain and liver cells. Its frequency increases in age‐related disorders and is one …
Correlation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival
Cooperative dysregulation of gene sequence and expression may contribute to cancer
formation and progression. The Cancer Genome Atlas (TCGA) Network recently catalogued …
formation and progression. The Cancer Genome Atlas (TCGA) Network recently catalogued …
The emerging importance of group II PAKs
CM Wells, GE Jones - Biochemical Journal, 2010 - portlandpress.com
The Rho-family GTPases Rho Rac and Cdc42 regulate many intracellular processes
through their interaction with downstream effector proteins. The PAKs (p21-activated …
through their interaction with downstream effector proteins. The PAKs (p21-activated …
PAK4 signaling in health and disease: Defining the PAK4–CREB axis
SY Won, JJ Park, EY Shin, EG Kim - Experimental & molecular …, 2019 - nature.com
Abstract p21-Activated kinase 4 (PAK4), a member of the PAK family, regulates a wide range
of cellular functions, including cell adhesion, migration, proliferation, and survival …
of cellular functions, including cell adhesion, migration, proliferation, and survival …
Role of p-21-activated kinases in cancer progression
H King, NS Nicholas, CM Wells - International review of cell and molecular …, 2014 - Elsevier
Abstract The p-21-activated kinases (PAKs) are downstream effectors of Rho GTPases Rac
and Cdc42. The PAK family consists of six members which are segregated into two …
and Cdc42. The PAK family consists of six members which are segregated into two …
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion
CM Wells, AD Whale, M Parsons… - Journal of cell …, 2010 - journals.biologists.com
Hepatocyte growth factor (HGF) is associated with tumour progression and increases the
invasiveness of prostate carcinoma cells. Migration and invasion require coordinated …
invasiveness of prostate carcinoma cells. Migration and invasion require coordinated …
LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells
P21-activated kinase 4 (PAK4), a serine/threonine protein kinase, has involved in the
regulation of cytoskeletal reorganization, cell proliferation, gene transcription, oncogenic …
regulation of cytoskeletal reorganization, cell proliferation, gene transcription, oncogenic …