Sarcopenia is the age‐related decline in muscle mass and function without any underlying
disease. The exact molecular mechanisms responsible for this pathology remain unknown …

Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing
dysfunctional ECM could potentially prevent age-related pathologies. Interventions …

The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

The developmental role of histone H3K9 methylation (H3K9me), which typifies
heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a …

Molecular chaperones are essential cellular components that aid in protein folding and
preventing the abnormal aggregation of disease-associated proteins. Mutations in one such …

Complex biological processes such as embryogenesis require precise coordination of cell
differentiation programs across both space and time. Using protein-fusion fluorescent …

Background Exercise exerts remarkably powerful effects on metabolism and health, with anti-
disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits …

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by
progressive muscle degeneration and weakness due to mutations in the dystrophin gene …

Exercise generates a site-specific increase in Reactive Oxygen Species (ROS) within
muscle that promotes changes in gene transcription and mitochondrial biogenesis, required …

Two novel collagen peptides derived from Yak bones, UU1 (GASGPMGPR) and K7
(GLPGPM) were demonstrated to be antioxidative in vitro and in Caenorhabditis elegans. In …