Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …

It has been known for decades that telomerase extends the 3′ end of linear eukaryotic
chromosomes and dictates the telomeric repeat sequence based on the template in its RNA …

Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation
and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to …

Long noncoding RNAs (lncRNAs) are key regulators of chromatin state, yet the nature and
sites of RNA-chromatin interaction are mostly unknown. Here we introduce Chromatin …

The Alternative Lengthening of Telomeres (ALT) pathway is a telomerase-independent
pathway for telomere maintenance that is active in a significant subset of human cancers …

Aging is a biological process characterized by a progressive functional decline in tissues
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Human chromosome ends are capped by shelterin, a protein complex that protects the
natural ends from being recognized as sites of DNA damage and also regulates the …