Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

The neuromuscular junction (NMJ) is a specialized synapse that bridges the motor neuron
and the skeletal muscle fiber and is crucial for conversion of electrical impulses originating …

Osteoporosis is an aging-related disease of reduced bone mass that is particularly prevalent
in post-menopausal women, but also affects the aged male population and is associated …

Neurodegeneration is a multifactorial process that involves multiple mechanisms. Examples
of neurodegenerative diseases are Parkinson's disease, multiple sclerosis, Alzheimer's …

The hallmark of spinal muscular atrophy (SMA), an inherited disease caused by ubiquitous
deficiency in the SMN protein, is the selective degeneration of subsets of spinal motor …

Charcot–Marie-Tooth disease type 2A (CMT2A) is an untreatable childhood peripheral
neuropathy caused by mutations of the mitochondrial fusion protein, mitofusin (MFN) 2 …

Cytotoxicity and consequent cell death pathways are a critical component of the immune
response to infection, disease or injury. While numerous examples of inflammation causing …

Nervous systems are arguably the most fascinating and complex structures in the known
universe. How they are built, changed by experience and then degenerate are some of the …

Developmental axon remodeling is characterized by the selective removal of branches from
axon arbors. The mechanisms that underlie such branch loss are largely unknown …

Animal behavior, from simple to complex, is dependent on the faithful wiring of neurons into
functional neural circuits. Neural circuits undergo dramatic experience-dependent …