Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

The extent of tissue regeneration varies widely between species. Mammals have a limited
regenerative capacity whilst lower vertebrates such as the zebrafish (Danio rerio), a …

Loss of sensory hair cells (HCs) in the mammalian inner ear leads to permanent hearing
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …

The CRISPR/Cas9 system has been used to generate fluorescently labelled fusion proteins
by homology-directed repair in a variety of species. Despite its revolutionary success, there …

Loss of mechanosensory hair cells in the inner ear leads to loss of hearing. In humans this
results in permanent deafness, as mammals are largely unable to regenerate hair cells. In …

Mechanosensory hair cells of the zebrafish lateral line regenerate rapidly following damage.
These renewed hair cells arise from the proliferation of surrounding support cells, which …

Fish use multiple sensory systems, including vision and their lateral line system, to maintain
position and speed within a school. Although previous studies have shown that ablating the …

Key points We investigated hair‐cell regeneration in the zebrafish lateral line following the
application of the ototoxic compound copper. In early‐larval zebrafish (< 10 days post …

Tissue-nonspecific alkaline phosphatase (TNAP) is a ubiquitously expressed enzyme that is
best known for its role during mineralization processes in bones and skeleton. The enzyme …

The sox2 expressing (sox2+) progenitors in adult mammalian inner ear lose the capacity to
regenerate while progenitors in the zebrafish lateral line are able to proliferate and …