Metabolic implications of organelle–mitochondria communication

I Gordaliza‐Alaguero, C Cantó, A Zorzano - EMBO reports, 2019 - embopress.org
Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …

Targeting long chain acyl-CoA synthetases for cancer therapy

M Rossi Sebastiano, G Konstantinidou - International journal of molecular …, 2019 - mdpi.com
The deregulation of cancer cell metabolic networks is now recognized as one of the
hallmarks of cancer. Abnormal lipid synthesis and extracellular lipid uptake are …

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

CL Chang, AV Weigel, MS Ioannou, HA Pasolli… - Journal of Cell …, 2019 - rupress.org
Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various
organelles including peroxisomes. Here, we show that the hereditary spastic paraplegia …

[HTML][HTML] Maintaining social contacts: The physiological relevance of organelle interactions

BSC Silva, L DiGiovanni, R Kumar… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate
and facilitate cellular functions. The formation of close contacts, termed “membrane contact …

Crosstalk between autophagy and metabolic regulation of cancer stem cells

M El Hout, E Cosialls, M Mehrpour, A Hamaï - Molecular cancer, 2020 - Springer
Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate
with each other and with host cells in their microenvironment. As circumstances change, the …

Organelle interplay—peroxisome interactions in health and disease

M Schrader, M Kamoshita… - Journal of Inherited …, 2020 - Wiley Online Library
Peroxisomes are multifunctional, dynamic, membrane‐bound organelles with important
functions in cellular lipid metabolism, rendering them essential for human health and …

Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications

R Rakotonirina-Ricquebourg, V Costa… - Progress in Lipid …, 2022 - Elsevier
Lipid droplets (LDs) are ubiquitous organelles that play crucial roles in response to
physiological and environmental cues. The identification of several neutral lipid synthesizing …

Peroxisomal ABC transporters: an update

A Tawbeh, C Gondcaille, D Trompier… - International Journal of …, 2021 - mdpi.com
ATP-binding cassette (ABC) transporters constitute one of the largest superfamilies of
conserved proteins from bacteria to mammals. In humans, three members of this family are …

The biochemistry and physiology of long-chain dicarboxylic acid metabolism

P Ranea-Robles, SM Houten - Biochemical Journal, 2023 - portlandpress.com
Mitochondrial β-oxidation is the most prominent pathway for fatty acid oxidation but
alternative oxidative metabolism exists. Fatty acid ω-oxidation is one of these pathways and …

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation

M Misheva, K Kotzamanis, LC Davies, VJ Tyrrell… - Nature …, 2022 - nature.com
Oxylipins are potent biological mediators requiring strict control, but how they are removed
en masse during infection and inflammation is unknown. Here we show that …