Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Ferroptosis, a cell death process driven by iron-dependent phospholipid peroxidation, has
been implicated in various diseases. There are two major surveillance mechanisms to …

Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the
orchestration of metabolic pathways in regulating ferroptosis will provide new insights into …

Ferroptosis is a mode of regulated cell death characterized by iron-dependent accumulation
of lipid peroxidation. It is closely linked to the pathophysiological processes in many …

Aims Cuproptosis is a recently identified form of programmed cell death; however, its role in
hepatocellular carcinoma (HCC) remains unclear. Methods A set of bioinformatic tools was …

Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However,
resistance to ICB occurs frequently due to tumor-intrinsic alterations or extrinsic factors in the …

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …