Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Protons dictate the charge and structure of macromolecules and are used as energy
currency by eukaryotic cells. The unique function of individual organelles therefore depends …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

This brief review of the human Na/H exchanger gene family introduces a new classification
with three subgroups to the SLC9 gene family. Progress in the structure and function of this …

Sodium/proton antiporters or exchangers (NHE) are integral membrane proteins present in
most, if not all, living organisms. In mammals, these transporters chiefly catalyze the …

Abstract Sodium/proton exchanger 1 (NHE1) is an electroneutral secondary active
transporter present on the plasma membrane of most mammalian cells and plays critical …

KCNQ channels belong to a family of potassium ion channels with crucial roles in
physiology and disease. Heteromers of KCNQ2/3 subunits constitute the neuronal M …