An organism's survival can depend on its ability to recall and navigate to spatial locations
associated with rewards, such as food or a home. Accumulating research has revealed that …

There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …

Animals associate cues with outcomes and update these associations as new information is
presented. This requires the hippocampus, yet how hippocampal neurons track changes in …

Odours are a fundamental part of the sensory environment used by animals to guide
behaviours such as foraging and navigation,. Primary olfactory (piriform) cortex is thought to …

The hippocampus has a well-established role in spatial and episodic memory but a broader
function has been proposed including aspects of perception and relational processing …

Adult-born granule cells (abGCs) have been implicated in memory discrimination through a
neural computation known as pattern separation. Here, using in vivo Ca 2+ imaging, we …

The convergence of internal path integration and external sensory landmarks generates a
cognitive spatial map in the hippocampus. We studied how localized odor cues are …

Olfactory information is encoded in lateral entorhinal cortex (LEC) by two classes of layer 2
(L2) principal neurons: fan and pyramidal cells. However, the functional properties of L2 …

Major depressive disorder is a common debilitating mental health problem that represents
one of the leading causes of disability. Up to date, the therapeutic targets and approaches …

Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal
function, which is suggestive of neurogenesis impairments, is associated with depression …