With the increasing use of genomic profiling for diagnosis and therapy guidance in many
tumor types, precision oncology is rapidly reshaping cancer care. However, the current …

The combination of next-generation sequencing and advanced computational data analysis
approaches has revolutionized our understanding of the genomic underpinnings of cancer …

Abstract The AACR Project GENIE is an international data-sharing consortium focused on
generating an evidence base for precision cancer medicine by integrating clinical-grade …

The advent of Next-Generation Sequencing (NGS) technologies has opened new
perspectives in deciphering the genetic mechanisms underlying complex diseases …

Early successes in identifying and targeting individual oncogenic drivers, together with the
increasing feasibility of sequencing tumor genomes, have brought forth the promise of …

Abstract The National Cancer Institute Genomic Data Commons (GDC) is an information
system for storing, analyzing, and sharing genomic and clinical data from patients with …

Multidisciplinary cancer care has an established position internationally and has been
recommended by cancer organizations, governments, and learned societies as best practice …

Precision oncology relies on accurate discovery and interpretation of genomic variants,
enabling individualized diagnosis, prognosis and therapy selection. We found that six …

Background Due to rapid technical advances, steeply declining sequencing costs, and the
ever-increasing number of targeted therapies, it can be expected that extensive tumor …

Patient genomes are interpretable only in the context of other genomes; however, genome
sharing enables discrimination. Thousands of monogenic diseases have yielded definitive …