Systematic review of Mendelian randomization studies on risk of cancer

G Markozannes, A Kanellopoulou, O Dimopoulou… - BMC medicine, 2022 - Springer
Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

[HTML][HTML] Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation

S Yuan, J Chen, L Dan, Y Xie, Y Sun, X Li… - The American Journal of …, 2022 - Elsevier
Background Circulating concentrations of homocysteine and folate are inconsistently
associated with the risk of nonalcoholic fatty liver disease (NAFLD) in observational studies …

An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses

JY Kim, M Song, MS Kim, P Natarajan, R Do, W Myung… - BMC medicine, 2023 - Springer
Background Micronutrients, namely vitamins and minerals, are associated with cancer
outcomes; however, their reported effects have been inconsistent across studies. We aimed …

Identifying and ranking causal biochemical biomarkers for breast cancer: a Mendelian randomisation study

SN Tang, V Zuber, KK Tsilidis - BMC medicine, 2022 - Springer
Background Only a few of the 34 biochemical biomarkers measured in the UK Biobank
(UKB) have been associated with breast cancer, with many associations suffering from …

Selenium and cancer risk: Wide‐angled Mendelian randomization analysis

S Yuan, AM Mason, P Carter… - … journal of cancer, 2022 - Wiley Online Library
Evidence on the association between selenium and cancer risk is inconclusive. We
conducted a Mendelian randomization study to examine the associations of selenium levels …

Mendelian randomization as a tool for causal inference in human nutrition and metabolism

SC Larsson - Current opinion in lipidology, 2021 - journals.lww.com
Mendelian randomization can be used as a tool to improve causal inference in
observational studies assessing the role of nutritional factors and metabolites in health and …

Inflammatory cytokines mediating the effect of oral lichen planus on oral cavity cancer risk: a univariable and multivariable mendelian randomization study

T Zheng, C Liu, Y Wang, H Zhou, R Zhou, X Zhu, Z Zhu… - BMC Oral Health, 2024 - Springer
Background While observational studies and experimental data suggest a link between oral
lichen planus (OLP) and oral cavity cancer (OCC), the causal relationship and the role of …

Impacts of matrix metalloproteinase-2 promoter genotypes on breast cancer risk

CC Hung, CL Tsai, YT Chin, YC Wang… - Cancer Genomics & …, 2024 - cgp.iiarjournals.org
Background/Aim: Matrix metalloproteinase-2 (MMP-2) has been implicated in the
pathogenesis of breast cancer (BC). However, there is limited research on the role of MMP-2 …

An exploration of the correlations between seven psychiatric disorders and the risks of breast cancer, breast benign tumors and breast inflammatory diseases …

F Ren, Q Shang, S Zhao, C Yang, K Feng, J Liu… - Frontiers in …, 2023 - frontiersin.org
Background Previous observational studies have showed that certain psychiatric disorders
may be linked to breast cancer risk, there is, however, little understanding of relationships …

Causal associations between dietary antioxidant vitamin intake and lung cancer: A Mendelian randomization study

H Zhao, X Jin - Frontiers in nutrition, 2022 - frontiersin.org
Background Oxidative stress is currently considered to be closely related to the occurrence
of respiratory tumors, especially lung cancer. Many observational studies have shown that …