High-valent metal–oxo species with multiply-bonded M–O groups have been proposed as
key intermediates in many biological and abiological catalytic oxidation reactions. These …

A growing subset of metalloenzymes activates dioxygen with nonheme diiron active sites to
effect substrate oxidations that range from the hydroxylation of methane and the …

Room-temperature molecular oxygen (O2) dissociation is challenging toward chemical
reactions due to its triplet ground-state and spin-forbidden characteristic. Herein, we …

Utilization of O2 as an abundant and environmentally benign oxidant is of great interest in
the design of bioinspired synthetic catalytic oxidation systems. Metalloenzymes activate O2 …

Structural regulation of the active centers is often pivotal in controlling the catalytic functions,
especially in iron-based oxidation systems. Here, we discovered a significantly altered …

The development of sustainable enantioselective olefin epoxidation and alkane oxidation
reactions under environmentally friendly conditions is an ultimate goal that has long been …

Abstract The 2-His-1-carboxylate facial triad is a widely used scaffold to bind the iron center
in mononuclear nonheme iron enzymes for activating dioxygen in a variety of oxidative …

Iron-based enzymes efficiently activate molecular oxygen to perform the oxidation of
methane to methanol (MTM), a reaction central to the contemporary chemical industry …

Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying
bioactive organic molecules in all major classes of natural product pathways. While the …

There are mechanistic dichotomies with regard to the formation, electronic structures and
reaction mechanisms of metal–oxygen intermediates, since these metal–oxygen species …