Chronic liver disease (CLD) is one of the leading causes of disability-adjusted life years in
many countries. A recent understanding of nuclear bile acid receptor pathways has …

Gallstones occur in about one third of the patients having liver cirrhosis. Pigment gallstones
are the most frequent type, while cholesterol stones represent about 15% of all stones in …

Bridging the gap between basic scientific advances and the understanding of liver disease—
the extensively revised new edition of the premier text in the field. The latest edition of The …

We describe a metabolic defect in bile acid synthesis involving a deficiency in 7alpha-
hydroxylation due to a mutation in the gene for the microsomal oxysterol 7alpha-hydroxylase …

Background The fasting‐state serum bile acid profile in nonalcoholic fatty liver disease
(NAFLD) has been reported to differ when nonalcoholic steatohepatitis is compared to …

The intestinal barrier, with its multiple layers, is the first line of defense between the outside
world and the intestine. Its disruption, resulting in increased intestinal permeability, is a …

Malnutrition is highly prevalent among patients with chronic liver disease and is nearly
universal among patients awaiting liver transplantation. Malnutrition in patients with cirrhosis …

Bile salts have deleterious effects on a variety of organs, cells, and subcellular organelles.
Several bile salts, predominantly monohydroxy bile salts, have the capacity to produce …

The liver plays a central role in the regulation of cholesterol homeostasis. Under normal
conditions, cholesterol input into the body equals output; cholesterol homeostasis is …

Increased bacterial deconjugation of bile acids was agsessed by measuring 14 CO 2
specific activity of breath samples taken at intervals after a meal containing cholyl-glycine-l …