Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle

GMG Shepherd, N Yamawaki - Nature Reviews Neuroscience, 2021 - nature.com
Functions of the neocortex depend on its bidirectional communication with the thalamus, via
cortico-thalamo-cortical (CTC) loops. Recent work dissecting the synaptic connectivity in …

Neocortical layer 1: an elegant solution to top-down and bottom-up integration

B Schuman, S Dellal, A Prönneke… - Annual review of …, 2021 - annualreviews.org
Many of our daily activities, such as riding a bike to work or reading a book in a noisy cafe,
and highly skilled activities, such as a professional playing a tennis match or a violin …

Paradoxical somatodendritic decoupling supports cortical plasticity during REM sleep

M Aime, N Calcini, M Borsa, T Campelo, T Rusterholz… - Science, 2022 - science.org
Rapid eye movement (REM) sleep is associated with the consolidation of emotional
memories. Yet, the underlying neocortical circuits and synaptic mechanisms remain unclear …

Cortical somatostatin interneuron subtypes form cell-type-specific circuits

SJ Wu, E Sevier, D Dwivedi, GA Saldi, A Hairston, S Yu… - Neuron, 2023 - cell.com
The cardinal classes are a useful simplification of cortical interneuron diversity, but such
broad subgroupings gloss over the molecular, morphological, and circuit specificity of …

[HTML][HTML] Cooperative thalamocortical circuit mechanism for sensory prediction errors

S Furutachi, AD Franklin, AM Aldea, TD Mrsic-Flogel… - Nature, 2024 - nature.com
The brain functions as a prediction machine, utilizing an internal model of the world to
anticipate sensations and the outcomes of our actions. Discrepancies between expected …

Learning how network structure shapes decision-making for bio-inspired computing

M Schirner, G Deco, P Ritter - Nature Communications, 2023 - nature.com
To better understand how network structure shapes intelligent behavior, we developed a
learning algorithm that we used to build personalized brain network models for 650 Human …

Anatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices

S El-Boustani, BS Sermet, G Foustoukos… - Nature …, 2020 - nature.com
Subdivisions of mouse whisker somatosensory thalamus project to cortex in a region-
specific and layer-specific manner. However, a clear anatomical dissection of these …

Layer 6b controls brain state via apical dendrites and the higher-order thalamocortical system

TA Zolnik, A Bronec, A Ross, M Staab, RNS Sachdev… - Neuron, 2024 - cell.com
The deepest layer of the cortex (layer 6b [L6b]) contains relatively few neurons, but it is the
only cortical layer responsive to the potent wake-promoting neuropeptide orexin/hypocretin …

Neuronal circuits in barrel cortex for whisker sensory perception

JF Staiger, CCH Petersen - Physiological reviews, 2021 - journals.physiology.org
The array of whiskers on the snout provides rodents with tactile sensory information relating
to the size, shape and texture of objects in their immediate environment. Rodents can use …

Precise movement-based predictions in the mouse auditory cortex

NJ Audette, WX Zhou, A La Chioma, DM Schneider - Current Biology, 2022 - cell.com
Many of the sensations experienced by an organism are caused by their own actions, and
accurately anticipating both the sensory features and timing of self-generated stimuli is …