microRNAs biogenesis, functions and role in tumor angiogenesis
T Annese, R Tamma, M De Giorgis, D Ribatti - Frontiers in oncology, 2020 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …
target more than one mRNAs, thus influencing multiple molecular pathways, but also …
Emerging roles of tRNA-derived fragments in cancer
M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer
H Liu, C Lei, Q He, Z Pan, D Xiao, Y Tao - Molecular cancer, 2018 - Springer
MicroRNAs (miRNAs) are endogenous non-coding RNAs that contain approximately 22
nucleotides. They serve as key regulators in various biological processes and their …
nucleotides. They serve as key regulators in various biological processes and their …
The rise of regulatory RNA
KV Morris, JS Mattick - Nature Reviews Genetics, 2014 - nature.com
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …
suggests that RNA is not only functional as a messenger between DNA and protein but also …
On the expanding roles of tRNA fragments in modulating cell behavior
R Magee, I Rigoutsos - Nucleic acids research, 2020 - academic.oup.com
The fragments that derive from transfer RNAs (tRNAs) are an emerging category of
regulatory RNAs. Known as tRFs, these fragments were reported for the first time only a …
regulatory RNAs. Known as tRFs, these fragments were reported for the first time only a …
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
MR Friedländer, SD Mackowiak, N Li… - Nucleic acids …, 2012 - academic.oup.com
Abstract microRNAs (miRNAs) are a large class of small non-coding RNAs which post-
transcriptionally regulate the expression of a large fraction of all animal genes and are …
transcriptionally regulate the expression of a large fraction of all animal genes and are …
The functional role of long non-coding RNA in human carcinomas
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
Understanding transgenerational epigenetic inheritance via the gametes in mammals
L Daxinger, E Whitelaw - Nature Reviews Genetics, 2012 - nature.com
It is known that information that is not contained in the DNA sequence—epigenetic
information—can be inherited from the parent to the offspring. However, many questions …
information—can be inherited from the parent to the offspring. However, many questions …
Molecular mechanisms of Dicer: endonuclease and enzymatic activity
MS Song, JJ Rossi - Biochemical journal, 2017 - portlandpress.com
The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA
pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA …
pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA …
Orchestrated intron retention regulates normal granulocyte differentiation
Intron retention (IR) is widely recognized as a consequence of mis-splicing that leads to
failed excision of intronic sequences from pre-messenger RNAs. Our bioinformatic analyses …
failed excision of intronic sequences from pre-messenger RNAs. Our bioinformatic analyses …