In vertebrates, multiciliated cells (MCCs) are terminally differentiated cells that line the
airway tracts, brain ventricles, and reproductive ducts. Each MCC contains dozens to …

Innate immunity of the mucosal surfaces provides the first-line defense from invading
pathogens and pollutants conferring protection from the external environment. Innate …

Histological and lineage immunofluorescence examination revealed that healthy conducting
airways of humans and animals harbor sporadic poorly differentiated epithelial patches …

The airway epithelial cell layer forms the first barrier between lung tissue and the outside
environment and is thereby constantly exposed to inhaled substances, including infectious …

The airway epithelium provides the first line of defense to the surrounding environment.
However, dysfunctions of this physical barrier are frequently observed in allergic diseases …

The airway epithelium is a critical component of the respiratory system, serving as a barrier
against inhaled pathogens and toxins. It is composed of various cell types, each with specific …

The airway epithelium, which lines the conducting airways, is central to the defense of the
lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that …

In vitro models of differentiated respiratory epithelium that allow high-throughput screening
are an important tool to explore new therapeutics for chronic respiratory diseases. In the …

Central nervous system diseases negatively affect patients and society. Providing successful
noninvasive treatments for these diseases is challenging because of the presence of the …

In vitro airway models are increasingly important for pathomechanistic analyses of
respiratory diseases. Existing models are limited in their validity by their incomplete cellular …