There is a growing recognition that gliomas are complex tumors composed of neoplastic and
non-neoplastic cells, which each individually contribute to cancer formation, progression …

CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …

Mononuclear phagocytic cells in the CNS used to be defined according to their anatomical
location and surface marker expression. Recently, this concept has been challenged by the …

An imbalance between remyelinating and demyelinating rates underlies degenerative
processes in demyelinating diseases such as multiple sclerosis. An optimal therapeutic …

Proper development and function of the mammalian central nervous system (CNS) depend
critically on the activity of parenchymal sentinels referred to as microglia. Although microglia …

Microglia are the resident macrophage population of the central nervous system (CNS).
Adequate microglial function is crucial for a healthy CNS. Microglia are not only the first …

Microglial cells constitute the resident macrophage population of the CNS. Recent in vivo
studies have shown that microglia carry out active tissue scanning, which challenges the …

HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5
or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral …

Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its
detachment from microtubules and formation of insoluble intracellular aggregates within the …

Microgliosis is a common response to multiple types of damage in the CNS. However, the
origin of the cells involved in this process is still controversial and the relative importance of …