TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …

Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

Cancer largely adheres to Darwinian selection. Evolutionary forces are prominent during
metastasis, the final and incurable disease stage, where cells acquire combinations of …

Recent years have seen an increasing number of genetically engineered pig models of
human diseases including cancer. We previously generated pigs with a modified TP53 …

Ferredoxin reductase (FDXR) is a mitochondrial flavoprotein that initiates electron transport
from NADPH to several cytochromes P450 via two electron carriers, ferredoxin 1 (FDX1) and …

p73, a p53 family member, undergoes alternative splicing at the 3′ end to produce multiple
isoforms, but their expression and activity are largely unknown. Thus, CRISPR was used to …

Background: Copper complex has been gaining much attention in anticancer research as a
targeted agent since cancer cells uptake more copper than non-cancerous cells. Our group …

TP73, a member of the p53 family, is expressed as TAp73 and ΔNp73 along with multiple C-
terminal isoforms (α− η). ΔNp73 is primarily expressed in neuronal cells and necessary for …

p53 mutations are prevalent in human cancers; approximately half of patients with
esophageal cancer present these mutations. Mutant p53 (mutp53) exerts oncogenic …