Autophagy is a self-eating cellular catabolic pathway, through which long-lived proteins,
damaged organelles and misfolded proteins are degraded and recycled for the …

Stroke is the leading cause of death and adult disability worldwide. Mitochondrial
dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) …

Autophagy of mitochondria, termed mitophagy, plays an important role in cerebral ischemia-
reperfusion (IR) injury, but the mechanism is not yet clear. Tissue-type plasminogen activator …

Mitophagy, the elimination of damaged mitochondria through autophagy, promotes neuronal
survival in cerebral ischemia. Previous studies found deficient mitophagy in ischemic …

Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell
contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is …

Ischemic stroke is one of the leading causes of death and also a major cause of adult
disability worldwide. Revascularization via reperfusion therapy is currently a standard …

Autophagy is an evolutionarily ancient mechanism that ensures the lysosomal degradation
of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including …

Mitochondria play an essential role in bioenergetics and respiratory functions for cell viability
through numerous biochemical processes. To maintain mitochondria quality control and …

Mitochondria autophagy, termed as mitophagy, is a mechanism of specific autophagic
elimination of mitochondria. Mitophagy controls the quality and the number of mitochondria …

Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and
oxidative stress, which are important factors contributing to the development of brain …