Recent advances in the vaccine development against Middle East respiratory syndrome-coronavirus

CY Yong, HK Ong, SK Yeap, KL Ho… - Frontiers in microbiology, 2019 - frontiersin.org
Middle East respiratory syndrome (MERS) is a deadly viral respiratory disease caused by
MERS-coronavirus (MERS-CoV) infection. To date, there is no specific treatment proven …

MERS-CoV: understanding the latest human coronavirus threat

A Chafekar, BC Fielding - Viruses, 2018 - mdpi.com
Human coronaviruses cause both upper and lower respiratory tract infections in humans. In
2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe …

Middle East respiratory syndrome: emergence of a pathogenic human coronavirus

AR Fehr, R Channappanavar… - Annual review of …, 2017 - annualreviews.org
In 2012, a zoonotic coronavirus was identified as the causative agent of Middle East
respiratory syndrome and was named MERS coronavirus (MERS-CoV). As of August 11 …

Direct observation of repeated infections with endemic coronaviruses

M Galanti, J Shaman - The Journal of infectious diseases, 2021 - academic.oup.com
Background Although the mechanisms of adaptive immunity to pandemic severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) are still unknown, the immune response …

The current and future state of vaccines, antivirals and gene therapies against emerging coronaviruses

LV Tse, RM Meganck, RL Graham… - Frontiers in microbiology, 2020 - frontiersin.org
Emerging coronaviruses (CoV) are constant global public health threats to society. Multiple
ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of …

Potential effects of coronaviruses on the liver: an update

X Wang, J Lei, Z Li, L Yan - Frontiers in Medicine, 2021 - frontiersin.org
The coronaviruses that cause notable diseases, namely, severe acute respiratory syndrome
(SARS), middle east respiratory syndrome (MERS) and coronavirus disease 2019 (COVID …

The immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine design strategies

S Molaei, M Dadkhah, V Asghariazar, C Karami… - International …, 2021 - Elsevier
The worldwide outbreak of SARS-CoV-2, severe acute respiratory syndrome coronavirus 2
as a novel human coronavirus, was the worrying news at the beginning of 2020. Since its …

Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2

MH Shahrajabian, W Sun, Q Cheng - Human vaccines & …, 2021 - Taylor & Francis
ABSTRACT SARS-CoV-2, the virus causing COVID-19, is a single-stranded RNA virus
belonging to the order Nidovirales, family Coronaviridae, and subfamily Coronavirinae …

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

A Li, J Yu, M Lu, Y Ma, Z Attia, C Shan, M Xue… - Nature …, 2018 - nature.com
Current efforts to develop Zika virus (ZIKV) subunit vaccines have been focused on pre-
membrane (prM) and envelope (E) proteins, but the role of NS1 in ZIKV-specific immune …

An updated roadmap for MERS-CoV research and product development: focus on diagnostics

C Kelly-Cirino, LT Mazzola, A Chua, CJ Oxenford… - BMJ global …, 2019 - gh.bmj.com
Diagnostics play a central role in the early detection and control of outbreaks and can
enable a more nuanced understanding of the disease kinetics and risk factors for the Middle …