Physiologically based pharmacokinetic (PBPK) models of small molecules have become
mainstream in drug development and in academic research. The use of PBPK models is …

Background Enhancing interoperability of bioinformatics knowledge bases is a high-priority
requirement to maximize data reusability and thus increase their utility such as the return on …

Physiologically based pharmacokinetic (PBPK) modelling is an important tool to predict drug
disposition in the body. Rabbits play a pivotal role as a highly valued small animal model …

Abstract Background and Objective The use of bedaquiline as a treatment option for drug-
resistant tuberculosis meningitis (TBM) is of interest to address the increased prevalence of …

Drug metabolism is one of the critical determinants of drug disposition throughout the body.
While traditionally associated with the liver, recent research has unveiled the presence and …

This review explores genetic contributors to drug interactions, known as drug-gene and drug-
drug-gene interactions (DGI and DDGI, respectively). This article is part of a mini-review …

Gastrointestinal first‐pass metabolism plays an important role in bioavailability and in drug–
drug interactions. Physiologically‐based pharmacokinetic (PBPK) modeling is a powerful …

Patients with severe and sometimes moderate hemophilia B are prophylactically treated with
factor IX concentrates to prevent bleeding. For some time now, various extended terminal …

Aim: Bedaquiline, pretomanid, and linezolid combination (BPaL) treatment against
Mycobacterium tuberculosis is promising yet safety and adherence concerns exist that …