Alzheimer's disease (AD) is the most important neurodegenerative disorder in Western
countries. Pathological phenotypes of neurodegeneration result from a combination of …

Cerebrovascular and neurodegenerative disorders affect one billion people around the
world and result from a combination of genomic, epigenomic, metabolic, and environmental …

Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

Histone acetylation is an epigenetic modification that plays a critical role in chromatin
remodelling and transcriptional regulation. There is increasing evidence that epigenetic …

Traditionally regarded to coordinate movement, the cerebellum also exerts non-motor
functions including the regulation of cognitive and behavioral processing, suggesting a …

Polysialated neural cell adhesion molecule (PSA-NCAM) is a membrane bound
glycoprotein widely expressed during nervous system development. While commonly …

Notwithstanding the considerable advances in the treatment options for schizophrenia, the
cognitive symptoms in particular are not receptive to antipsychotic treatment and considered …

Epigenetic regulation, such as DNA methylation and histone modification, is implicated in
the aberrant changes in gene expression that occur during the progression of …

One of the newest frontiers of physical therapy is the field of epigenetics, which examines
how pervasive environmental factors such as exercise regulate the expression of genes …

Background Tissue microarrays are commonly used to evaluate disease pathology however
methods to automate and quantify pathological changes are limited. New method This …