Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Certain morphological, physiological and molecular characteristics are shared by all
neurons. However, despite these similarities, neurons constitute the most diverse cell …

Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

Annotating the molecular basis of human disease remains an unsolved challenge, as 93%
of disease loci are non-coding and gene-regulatory annotations are highly incomplete …

Although all human tissues carry out common processes, tissues are distinguished by gene
expression patterns, implying that distinct regulatory programs control tissue specificity. In …

We present WhichTF, a computational method to identify functionally important transcription
factors (TFs) from chromatin accessibility measurements. To rank TFs, WhichTF applies an …

Depression is a complex, heterogeneous disorder and a leading contributor to the global
burden of disease. Most previous research has focused on individual brain regions and …

Neurogenic transcription factors and evolutionarily conserved signalling pathways have
been found to be instrumental in the formation of neurons,. However, the instructive role of …

Conditional mutagenesis permits the cell type‐specific analysis of gene functions in vivo.
Here, we describe a mouse line that expresses Cre recombinase under control of regulatory …

Transcription factors with bHLH motifs modulate critical events in the development of the
mammalian neocortex. Multipotent cortical progenitors are maintained in a proliferative state …