Role of tau protein in Alzheimer's disease: The prime pathological player

S Muralidar, SV Ambi, S Sekaran, D Thirumalai… - International journal of …, 2020 - Elsevier
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

Tau proteins and tauopathies in Alzheimer's disease

FP Chong, KY Ng, RY Koh, SM Chye - Cellular and molecular …, 2018 - Springer
Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
function deficits. There are two major pathological hallmarks that contribute to the …

Role of tau as a microtubule-associated protein: structural and functional aspects

P Barbier, O Zejneli, M Martinho, A Lasorsa… - Frontiers in aging …, 2019 - frontiersin.org
Microtubules (MTs) play a fundamental role in many vital processes such as cell division
and neuronal activity. They are key structural and functional elements in axons, supporting …

Microtubules gate tau condensation to spatially regulate microtubule functions

R Tan, AJ Lam, T Tan, J Han, DW Nowakowski… - Nature cell …, 2019 - nature.com
Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into
insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia, yet the …

Alzheimer's disease: targeting the glutamatergic system

ME Conway - Biogerontology, 2020 - Springer
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that causes a
progressive decline in memory, language and problem solving. For decades mechanism …

ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule‐associated proteins

A Ramkumar, BY Jong… - Developmental …, 2018 - Wiley Online Library
Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

T Briston, AR Hicks - Biochemical Society Transactions, 2018 - portlandpress.com
Neurodegenerative proteinopathies are a group of pathologically similar, progressive
disorders of the nervous system, characterised by structural alterations within and toxic …

The role of glycogen synthase kinase 3 beta in neurodegenerative diseases

H Yu, M Xiong, Z Zhang - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …

Neurodegenerative diseases: their onset, epidemiology, causes and treatment

S Zaib, H Javed, I Khan, F Jaber, A Sohail… - …, 2023 - Wiley Online Library
Neurodegenerative diseases are a group of diseases with several neuropathological
symptoms. Degenerative nerve diseases can be serious or life‐threatening. Because of the …

Potential neuroprotection by Dendrobium nobile Lindl alkaloid in Alzheimer's disease models

DD Li, CQ Zheng, F Zhang, JS Shi - Neural Regeneration …, 2022 - journals.lww.com
At present, treatments for Alzheimer's disease can temporarily relieve symptoms but cannot
prevent the decline of cognitive ability and other neurodegenerative changes. Dendrobium …