Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis

Y Wang, S Chen, K Du, C Liang, S Wang… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Rheumatoid arthritis (RA) is a chronic inflammatory
autoimmune disease influenced by diverse endogenous and exogenous factors. It is …

Pathogenic role of immune cells in rheumatoid arthritis: implications in clinical treatment and biomarker development

HY Yap, SZY Tee, MMT Wong, SK Chow, SC Peh… - Cells, 2018 - mdpi.com
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that
affects synovial joints, both small and large joints, in a symmetric pattern. This disorder …

Selective JAKinibs: prospects in inflammatory and autoimmune diseases

AT Virtanen, T Haikarainen, J Raivola, O Silvennoinen - BioDrugs, 2019 - Springer
Cytokines, many of which signal through the JAK–STAT (Janus kinase–Signal Transducers
and Activators of Transcription) pathway, play a central role in the pathogenesis of …

Route to rheumatoid arthritis by macrophage-derived microvesicle-coated nanoparticles

R Li, Y He, Y Zhu, L Jiang, S Zhang, J Qin, Q Wu… - Nano …, 2018 - ACS Publications
The targeted delivery of therapeutics to sites of rheumatoid arthritis (RA) has been a long-
standing challenge. Inspired by the intrinsic inflammation-targeting capacity of …

Targeting probiotics in rheumatoid arthritis

SG Bungau, T Behl, A Singh, A Sehgal, S Singh… - Nutrients, 2021 - mdpi.com
Rheumatoid arthritis (RA) is a progressive inflammatory disorder characterized by swollen
joints, discomfort, tightness, bone degeneration and frailty. Genetic, agamogenetic and sex …

Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis

A Gioxari, AC Kaliora, F Marantidou, DP Panagiotakos - Nutrition, 2018 - Elsevier
Objectives Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disease of
multiple joints that puts the patient at high risk for developing cardiovascular diseases …

Inhibition of MMPs and ADAM/ADAMTS

CJ Malemud - Biochemical pharmacology, 2019 - Elsevier
Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM)
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …

The role of female hormonal factors in the development of rheumatoid arthritis

D Alpízar-Rodríguez, N Pluchino, G Canny… - …, 2017 - academic.oup.com
RA is the most common chronic systemic autoimmune disease, with a higher prevalence in
women, suggesting female hormonal factors play a role in the development of the disease …

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis

S Singh, TG Singh, K Mahajan… - Journal of Pharmacy …, 2020 - academic.oup.com
Objectives Rheumatoid arthritis is a chronic autoimmune disease manifested clinically by
polyarthralgia associated with joint dysfunction triggering the antibodies targeting against …