Photoreceptor dysfunctions and degenerative diseases are significant causes of vision loss
in patients, with few effective treatments available. Targeted interventions to prevent or …

Zebrafish are an instrumental system for the generation of photoreceptor degeneration
models, which can be utilized to determine underlying causes of photoreceptor dysfunction …

Background & Aims In the developing liver, bipotent epithelial progenitor cells undergo
lineage segregation to form hepatocytes, which constitute the bulk of the liver parenchyma …

Mutations in the Joubert syndrome-associated small GTPase ARL13B are linked to
photoreceptor impairment and vision loss. To determine the role of ARL13B in the …

Photoreceptor degeneration leads to irreversible vision loss in humans with retinal
dystrophies such as retinitis pigmentosa. Whereas photoreceptor loss is permanent in …

Mutations in the gene Centrosomal Protein 290 kDa (CEP290) result in multiple ciliopathies
ranging from the neonatal lethal disorder Meckel-Gruber Syndrome to multi-systemic …

Photoreceptors are polarized neurons, with very specific subcellular compartmentalization
and unique requirements for protein expression and trafficking. Each photoreceptor contains …

Eye and inner ear diseases are the most common sensory impairments that greatly impact
quality of life. Zebrafish have been intensively employed to understand the fundamental …

Abstract Purpose of Review Retinal degenerative diseases have immense socio-economic
impact. Studying animal models that recapitulate human eye pathologies aids in …

Cilia are quasi-ubiquitous microtubule-based sensory organelles, which play vital roles in
signal transduction during development and cell homeostasis. Dysfunction of cilia leads to a …