The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

A growing body of evidence indicates that, over the course of evolution of the immune
system, arginine has been selected as a node for the regulation of immune responses. An …

In a state of oxidative stress, there is an increase of reactive species, which induce an
altered intracellular signaling, leading to dysregulation of the inflammatory response. The …

The reversible oxidation-reduction homeostasis mechanism functions as a specific signal
transduction system, eliciting related physiological responses. Disruptions to redox …

It is more effective to maintain good health than to regain it after losing it. This work focuses
on the biochemical defense mechanisms against free radicals and their role in building and …

MicroRNAs (miRNAs) are a class of small, mature, noncoding RNA that lead to
posttranscriptional gene silencing to regulate gene expression. miRNAs are instrumental in …

Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …

Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis
of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead …

T cells are central to all currently effective cancer immunotherapies, but the characteristics
defining therapeutically effective anti-tumor T cells have not been comprehensively …

CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon
tumor antigen stimulation, and then differentiate into functional cells and migrate towards the …