Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

The monoclonal anti‐immunoglobulin E (IgE) antibody, omalizumab, was the first drug
approved for use in patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) who …

Mast cells are unique tissue‐resident immune cells that secrete a diverse array of
biologically active compounds that can stimulate, modulate, or suppress the immune …

Mast cells and basophils are key contributors to allergies and other inflammatory diseases
since they are the most prominent source of histamine as well as numerous additional …

Asthma is a chronic airway inflammatory disease that is influenced by the interplay between
genetic factors and exposure to environmental allergens, microbes, or microbial products …

In recent years, an association between hypermobile Ehlers-Danlos syndrome (hEDS), mast
cell activation syndrome (MCAS), and postural orthostatic tachycardia syndrome (POTS) has …

Human mast cells (MCs) and eosinophils were first described and named by Paul Ehrlich.
These cells have distinct myeloid progenitors and differ morphologically, ultrastructurally …

Mast cells are tissue resident, innate immune cells with heterogenous phenotypes tuned by
cytokines and other microenvironmental stimuli. Playing a protective role in parasitic …

The complexity of the pathogenetic mechanisms of the development of chronic inflammation
in asthma determines its heterogeneity and insufficient treatment effectiveness. Nuclear …

Mast cells are strategically located in different compartments of the lung in asthmatic
patients. These cells are widely recognized as central effectors and immunomodulators in …