Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment

TH Bisgaard, KH Allin, L Keefer… - Nature reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a
chronic, relapsing immune-mediated disease with a varying and sometimes severe disease …

Inflammation from peripheral organs to the brain: how does systemic inflammation cause neuroinflammation?

Y Sun, Y Koyama, S Shimada - Frontiers in aging neuroscience, 2022 - frontiersin.org
As inflammation in the brain contributes to several neurological and psychiatric diseases,
the cause of neuroinflammation is being widely studied. The causes of neuroinflammation …

Stress triggers flare of inflammatory bowel disease in children and adults

Y Sun, L Li, R Xie, B Wang, K Jiang, H Cao - Frontiers in pediatrics, 2019 - frontiersin.org
Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease characterized by
chronic and relapsing manifestations. It is noteworthy that the prevalence of IBD is gradually …

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

C Tan, Q Yan, Y Ma, J Fang, Y Yang - Frontiers in Neurology, 2022 - frontiersin.org
Depression is a worldwide disease causing severe disability, morbidity, and mortality.
Despite abundant studies, the precise mechanisms underlying the pathophysiology of …

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

L Ge, S Liu, S Li, J Yang, G Hu, C Xu… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), mainly including ulcerative colitis (UC) and Crohn's
disease (CD), is an autoimmune gastrointestinal disease characterized by chronic …

The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors …

K Wu, Y Liu, S Shao, W Song, X Chen, Y Dong… - Brain, Behavior, and …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a chronic condition with a high recurrence rate. To date,
the clinical treatment of IBD mainly focuses on inflammation and gastrointestinal symptoms …

Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease

CF Craig, RT Filippone, R Stavely, JC Bornstein… - Journal of …, 2022 - Springer
Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than
the general population. An etiological trigger of depressive symptoms is theorised to be …

The gut–immune–brain axis: an important route for neuropsychiatric morbidity in inflammatory bowel disease

RK Masanetz, J Winkler, B Winner, C Günther… - International Journal of …, 2022 - mdpi.com
Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis
(UC) and is associated with neuropsychiatric symptoms like anxiety and depression. Both …

Ferulic acid: An extraordinarily neuroprotective phenolic acid with anti-depressive properties

X Dong, R Huang - Phytomedicine, 2022 - Elsevier
Background Depression, one of the most common mental illnesses and mood disorder
syndromes, can seriously harm physical and mental health. As the pathophysiology of …

The role of the gut–brain axis in inflammatory bowel disease and its therapeutic implications

C Riggott, AC Ford, DJ Gracie - Alimentary Pharmacology & …, 2024 - Wiley Online Library
Background Treatments targeting the gut–brain axis (GBA) are effective at reducing
symptom burden in irritable bowel syndrome (IBS). The prevalence of common mental …