Current status and future perspectives in targeted therapy of NPM1-mutated AML
Abstract Nucleophosmin 1 (NPM1) is a nucleus-cytoplasmic shuttling protein which is
predominantly located in the nucleolus and exerts multiple functions, including regulation of …
predominantly located in the nucleolus and exerts multiple functions, including regulation of …
Biological and clinical consequences of NPM1 mutations in AML
Acute myeloid leukemia (AML) is characterized by accumulation of myeloid cells in the bone
marrow because of impaired differentiation and proliferation, resulting in hematopoietic …
marrow because of impaired differentiation and proliferation, resulting in hematopoietic …
Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
After the discovery of NPM1-mutated acute myeloid leukemia (AML) in 2005 and its
subsequent inclusion as a provisional entity in the 2008 World Health Organization …
subsequent inclusion as a provisional entity in the 2008 World Health Organization …
Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications
Nucleophosmin (NPM1) is a highly conserved nucleo-cytoplasmic shuttling protein that
shows a restricted nucleolar localization. Mutations of NPM1 gene leading to aberrant …
shows a restricted nucleolar localization. Mutations of NPM1 gene leading to aberrant …
Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity
R Rau, P Brown - Hematological oncology, 2009 - Wiley Online Library
Nucleophosmin (NPM) is a ubiquitously expressed chaperone protein that shuttles rapidly
between the nucleus and cytoplasm, but predominantly resides in the nucleolus. It plays key …
between the nucleus and cytoplasm, but predominantly resides in the nucleolus. It plays key …
AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features
C Haferlach, C Mecucci, S Schnittger… - Blood, The Journal …, 2009 - ashpublications.org
Acute myeloid leukemia (AML) with mutated NPM1 usually carries normal karyotype (NK),
but it may harbor chromosomal aberrations whose significance remains unclear. We …
but it may harbor chromosomal aberrations whose significance remains unclear. We …
Mutational landscape of AML with normal cytogenetics: biological and clinical implications
MP Martelli, P Sportoletti, E Tiacci, MF Martelli, B Falini - Blood reviews, 2013 - Elsevier
Acute myeloid leukemia (AML) is a molecularly heterogeneous disease. Based on
cytogenetics and FISH, AML patients are stratified into three major risk categories …
cytogenetics and FISH, AML patients are stratified into three major risk categories …
NPM1‐mutated acute myeloid leukemia: New pathogenetic and therapeutic insights and open questions
B Falini - American journal of hematology, 2023 - Wiley Online Library
The nucleophosmin (NPM1) gene encodes for a multifunctional chaperone protein that is
localized in the nucleolus but continuously shuttles between the nucleus and cytoplasm …
localized in the nucleolus but continuously shuttles between the nucleus and cytoplasm …
Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)
B Falini, K Macijewski, T Weiss… - Blood, The Journal …, 2010 - ashpublications.org
NPM1-mutated acute myeloid leukemia (AML) is a provisional entity in the 2008 World
Health Organization (WHO) classification of myeloid neoplasms. The significance of …
Health Organization (WHO) classification of myeloid neoplasms. The significance of …
Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field
B Falini, S Sciabolacci, L Falini, L Brunetti, MP Martelli - Leukemia, 2021 - nature.com
Mutations of Nucleophosmin (NPM1) are the most common genetic abnormalities in adult
acute myeloid leukaemia (AML), accounting for about 30% of cases. NPM1-mutated AML …
acute myeloid leukaemia (AML), accounting for about 30% of cases. NPM1-mutated AML …