Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Ovarian cancer is a malignant tumor of the female reproductive system, with a very poor
prognosis and high mortality rates. Chemotherapy and radiotherapy are the most common …

Simple Summary Environmental light exposure is an important factor for human health that
impacts the biological clock of organisms. Melatonin usually serves as a chemical …

Melatonin is a pineal indolamine, allegedly known as a circadian rhythm regulator, and an
antioxidative and immunomodulatory molecule. In both experimental and clinical trials …

The endoplasmic reticulum (ER) is crucial for protein quality control, and disruptions in its
function can lead to various diseases. ER stress triggers an adaptive response called the …

The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

This review is focused on the mechanisms that regulate health, disease and aging redox
status, the signal pathways that counteract oxidative and reductive stress, the role of food …

Pulmonary fibrosis (PF) is a chronic interstitial lung disease with no effective therapies.
Galectin-3 (Gal-3), a marker of oxidative stress, plays a key role in the pathogenesis of PF …

Mitochondria functionally degrade as neurons age. Degenerative changes cause inefficient
oxidative phosphorylation (OXPHOS) and elevated electron leakage from the electron …

Melatonin is a neurohormone that is mainly secreted by the pineal gland. It coordinates the
work of the superior biological clock and consequently affects many processes in the human …