Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium

M Packer - Journal of the American College of Cardiology, 2018 - jacc.org
Epicardial adipose tissue has unique properties that distinguish it from other depots of
visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed …

Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease

JJ Fuster, N Ouchi, N Gokce, K Walsh - Circulation research, 2016 - Am Heart Assoc
Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

Guidelines for the measurement of vascular function and structure in isolated arteries and veins

CF Wenceslau, CG McCarthy… - American Journal …, 2021 - journals.physiology.org
The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …

Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Perivascular adipose tissue inflammation in vascular disease

R Nosalski, TJ Guzik - British journal of pharmacology, 2017 - Wiley Online Library
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of
cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in …

Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease

VB Patel, S Shah, S Verma, GY Oudit - Heart failure reviews, 2017 - Springer
Obesity and diabetes are strongly associated with metabolic and cardiovascular disorders
including dyslipidemia, coronary artery disease, hypertension, and heart failure. Adipose …

Newly identified regulators of ovarian folliculogenesis and ovulation

E Gershon, N Dekel - International journal of molecular sciences, 2020 - mdpi.com
Each follicle represents the basic functional unit of the ovary. From its very initial stage of
development, the follicle consists of an oocyte surrounded by somatic cells. The oocyte …

Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart

G Iacobellis, D Corradi, AM Sharma - Nature clinical practice …, 2005 - nature.com
A growing amount of evidence suggests that regional fat distribution plays an important part
in the development of an unfavorable metabolic and cardiovascular risk profile. Epicardial …

Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study

GA Rosito, JM Massaro, U Hoffmann, FL Ruberg… - Circulation, 2008 - Am Heart Assoc
Background—Pericardial fat may be an important mediator of metabolic risk. Correlations
with cardiovascular disease risk factors and vascular calcification in a community-based …

Perivascular adipose tissue in vascular function and disease: a review of current research and animal models

NK Brown, Z Zhou, J Zhang, R Zeng, J Wu… - … , and vascular biology, 2014 - Am Heart Assoc
Perivascular adipose tissue (PVAT), long assumed to be nothing more than vessel-
supporting connective tissue, is now understood to be an important, active component of the …