Over the past decades, tRNA was found to be a rich hub of RNA modifications such as 1-
methyladenosine and 5-methycytosine modifications and others, holding more than half of …

Modified uridine containing taurine, 5-taurinomethyluridine (τm5U), is found at the anticodon
first position of mitochondrial (mt-) transfer RNAs (tRNAs). Previously, we reported that τm5U …

Transfer RNA (tRNA) modifications play an important role in regulating mRNA translation at
the codon level. tRNA modifications can influence codon selection and optimality, thus …

Defective nucleotide modifications of mitochondrial tRNAs have been associated with
several human diseases, but their pathophysiology remains poorly understood. In this …

Several mitochondrial tRNA mutations have been associated with maternally inherited
diabetes and deafness. However, the pathophysiology of these tRNA mutations remains …

GTPBP3 is a highly conserved tRNA modifying enzyme for the biosynthesis of τm5U at the
wobble position of mitochondrial tRNAGlu, tRNAGln, tRNALys, tRNATrp and tRNALeu …

Bioinformatics approaches have proven useful in understanding biological responses to
spaceflight. Spaceflight experiments remain resource intensive and rare. One outstanding …

Background Mitochondria have the profound impact on vascular function in both health and
disease. However, mitochondrial genetic determinants for the development of hypertension …

Mutations in the mitochondrial tRNAs have been reported to be the important cause of
hearing loss. However, only a few cases have been identified thus far and the prevalence of …

In this report, we investigated the pathogenic mechanism underlying the deafness-
associated mitochondrial (mt) tRNAAsp 7551A> G mutation. The m. 7551A> G mutation is …