Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …

Despite lipid nanoparticles'(LNPs) success in the effective and safe delivery of mRNA
vaccines, an inhalation-based mRNA therapy for lung diseases remains challenging. LNPs …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and
limited treatment options. Efforts to identify effective treatments are thwarted by limited …

Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …

Background Silicosis is one of the most common occupational pulmonary fibrosis caused by
respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a …

Endometriosis negatively impacts the health-related quality of life of 190 million women
worldwide. Novel advances in nonhormonal treatments for this debilitating condition are …

Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9–
responsive cell repertoire is still not well defined. Here, we found that IL-9 mediates …

Alveolar macrophages (AMs) are highly abundant lung cells with important roles in
homeostasis and immunity. Their function influences the outcome of lung infections, lung …

Tissue-resident macrophages in the mammary gland are found in close association with
epithelial structures and within the adipose stroma, and are important for mammary gland …