How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?

VT Cong, JL Houng, M Kavallaris, X Chen… - Chemical Society …, 2022 - pubs.rsc.org
Targeted drug delivery in cancer typically focuses on maximising the endocytosis of drugs
into the diseased cells. However, there has been less focus on exploiting the differences in …

Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking

P Makvandi, M Chen, R Sartorius, A Zarrabi… - Nano Today, 2021 - Elsevier
Humans are exposed to nanoscopical nanobiovectors (eg coronavirus SARS-CoV-2) as
well as abiotic metal/carbon-based nanomaterials that enter cells serendipitously or …

Nanoparticle size effects in biomedical applications

J Dolai, K Mandal, NR Jana - ACS Applied Nano Materials, 2021 - ACS Publications
Nanoparticle size plays a central role in determining material properties and performance in
biomedical applications. A wide variety of functional nanomaterials and nano-bioconjugates …

Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy

W Du, S Du, X Dong, H Bai, J Jiang, S Hao, F Yang… - Biomaterials, 2023 - Elsevier
Cell nucleus is the desired subcellular organelle of many therapeutic drugs. Although
numerous nanomaterial-based methods have been developed which could facilitate nuclear …

Nuclear Transport of the Molecular Drug via Nanocarrier-Based Nonendocytic Cellular Uptake

AK Sarkar, S Shaw, H Arora, P Seth… - ACS Applied Materials & …, 2023 - ACS Publications
Although subcellular targeting can enhance the therapeutic performance of most drugs,
such targeting requires appropriate carrier-based delivery that can bypass …

Enhanced Ocular Delivery of Beva via Ultra‐Small Polymeric Micelles for Noninvasive Anti‐VEGF Therapy

R Yang, S Tang, X Xie, C Jin, Y Tong… - Advanced …, 2024 - Wiley Online Library
Pathological ocular neovascularization resulting from retinal ischemia constitutes a major
cause of vision loss. Current anti‐VEGF therapies rely on burdensome intravitreal injections …

Chemically designed nanoscale materials for controlling cellular processes

K Debnath, S Pal, NR Jana - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Nanoparticles are widely used in various biomedical applications as drug
delivery carriers, imaging probes, single-molecule tracking/detection probes, artificial …

Environmental nanoparticles reach human fetal brains

L Calderón-Garcidueñas, ÁA Pérez-Calatayud… - Biomedicines, 2022 - mdpi.com
Anthropogenic ultrafine particulate matter (UFPM) and industrial and natural nanoparticles
(NPs) are ubiquitous. Normal term, preeclamptic, and postconceptional weeks (PCW) 8–15 …

Controllable gold nanocluster–emulsion interface for direct cell penetration and photothermal killing

N Yang, Y Kang, Y Cong, X Wang, C Yao… - Advanced …, 2023 - Wiley Online Library
In the view of their ability to be uptaken by cells, colloidal particles can exert diverse
physiological effects and are promising vehicles for the intracellular delivery of biologically …

Arginine Surface Density of Nanoparticles Controls Nonendocytic Cell Uptake and Autophagy Induction

R Ray, S Ghosh, A Maity, NR Jana - ACS Applied Materials & …, 2024 - ACS Publications
Nonendocytic cell uptake of nanomaterials is challenging, which requires specific surface
chemistry and smaller particle size. Earlier works have shown that an arginine-terminated …