Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …

The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …

Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint
immobilization and bed rest, and is induced by a combination of unloading and inactivity …

Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the
development of various diseases, including heart failure. However, the molecular …

The ever increasing burden of an aging population and pandemic of metabolic syndrome
worldwide demands further understanding of the modifiable risk factors in reducing disability …

This investigation examined the effects of acute resistance exercise (RE), progressive
resistance training (PRT), and age on the human skeletal muscle Transcriptome. Two …

Background The construct of physical frailty and sarcopenia (PF&S) identifies an age-related
pre-disability condition defined by reduced physical performance and low muscle mass …

The transcriptional factor NF-κB is a nuclear factor involved in both physiological and
pathological processes. This factor can control the transcription of more than 400 genes …

The inhibitory IκB proteins have been discovered as fundamental regulators of the inducible
transcription factor nuclear factor‐κB (NF‐κB). As a generally excepted model, stimulus …

Disuse is a potent inducer of muscle atrophy, but the molecular mechanisms driving this loss
of muscle mass are highly debated. In particular, the extent to which disuse triggers …