The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is
differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma …

Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

Lipid droplets (LDs) are dynamic, cytosolic lipid‐storage organelles found in nearly all cell
types. Too many or too few LDs during excess or deficient fat storage lead to many different …

Context: Lipodystrophies are heterogeneous, genetic or acquired disorders characterized by
selective loss of body fat and predisposition to insulin resistance. The extent of fat loss …

Congenital generalized lipodystrophy (CGL) is a heterogeneous autosomal recessive
disorder characterized by a near complete lack of adipose tissue from birth and, later in life …

Caveolae are small, bulb-shaped plasma membrane invaginations. Mutations that ablate
caveolae lead to diverse phenotypes in mice and humans, making it challenging to uncover …

Insulin resistance is among the most prevalent endocrine derangements in the world, and it
is closely associated with major diseases of global reach including diabetes mellitus …

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling
organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most …

Lipodystrophies are the result of a range of inherited and acquired causes, but all are
characterized by perturbations in white adipose tissue function and, in many instances, its …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …