Fighting external pathogens requires an ever-changing immune system that relies on tight regulation of gene expression. Transcriptional control is the first step to build efficient …
The RNA N 6-methyladenosine (m 6 A) methylation is installed by the METTL3-METTL14 methyltransferase complex. This modification has critical regulatory roles in various …
T Inoue, R Shinnakasu, C Kawai, W Ise… - Journal of Experimental …, 2020 - rupress.org
A still unanswered question is what drives the small fraction of activated germinal center (GC) B cells to become long-lived quiescent memory B cells. We found here that a small …
T Inoue, R Shinnakasu, W Ise, C Kawai… - Journal of Experimental …, 2017 - rupress.org
Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How …
The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts …
M Ghashghaei, Y Liu, J Ettles, G Bombaci… - Nature …, 2024 - nature.com
Protein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is …
V Vikova, M Jourdan, N Robert, G Requirand… - Theranostics, 2019 - ncbi.nlm.nih.gov
Human multiple myeloma tumor cell lines (HMCLs) have been a cornerstone of research in multiple myeloma (MM) and have helped to shape our understanding of molecular …
T Yamaguchi, T Suzuki, T Sato, A Takahashi… - Science …, 2018 - science.org
Shortening and removal of the polyadenylate [poly (A)] tail of mRNA, a process called deadenylation, is a key step in mRNA decay that is mediated through the CCR4-NOT …
MA Collart, OO Panasenko - Macromolecular Protein Complexes: Structure …, 2017 - Springer
Abstract The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that …