RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

Fighting external pathogens requires an ever-changing immune system that relies on tight
regulation of gene expression. Transcriptional control is the first step to build efficient …

The RNA N 6-methyladenosine (m 6 A) methylation is installed by the METTL3-METTL14
methyltransferase complex. This modification has critical regulatory roles in various …

A still unanswered question is what drives the small fraction of activated germinal center
(GC) B cells to become long-lived quiescent memory B cells. We found here that a small …

Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone
(DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How …

The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on
TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts …

Protein synthesis is frequently deregulated during tumorigenesis. However, the precise
contexts of selective translational control and the regulators of such mechanisms in cancer is …

Human multiple myeloma tumor cell lines (HMCLs) have been a cornerstone of research in
multiple myeloma (MM) and have helped to shape our understanding of molecular …

Shortening and removal of the polyadenylate [poly (A)] tail of mRNA, a process called
deadenylation, is a key step in mRNA decay that is mediated through the CCR4-NOT …

Abstract The Ccr4-Not complex is an essential multi-subunit protein complex that plays a
fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that …