Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

The anaerobic threshold (AT) remains a widely recognized, and contentious, concept in
exercise physiology and medicine. As conceived by Karlman Wasserman, the AT coalesced …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

After a century, it's time to turn the page on understanding of lactate metabolism and
appreciate that lactate shuttling is an important component of intermediary metabolism in …

No longer viewed as a metabolic waste product and cause of muscle fatigue, a
contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in …