Multifaceted role of PARP-1 in DNA repair and inflammation: pathological and therapeutic implications in cancer and non-cancer diseases
S Pazzaglia, C Pioli - Cells, 2019 - mdpi.com
PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
On PAR with PARP: cellular stress signaling through poly (ADP-ribose) and PARP-1
X Luo, WL Kraus - Genes & development, 2012 - genesdev.cshlp.org
Cellular stress responses are mediated through a series of regulatory processes that occur
at the genomic, transcriptional, post-transcriptional, translational, and post-translational …
at the genomic, transcriptional, post-transcriptional, translational, and post-translational …
A data-driven drug repositioning framework discovered a potential therapeutic agent targeting COVID-19
The global spread of SARS-CoV-2 requires an urgent need to find effective therapeutics for
the treatment of COVID-19. We developed a data-driven drug repositioning framework …
the treatment of COVID-19. We developed a data-driven drug repositioning framework …
NF-κB, the first quarter-century: remarkable progress and outstanding questions
The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …
organisms, the ability to respond to external changes is essential not only for survival but …
PARP-1 involvement in neurodegeneration: a focus on Alzheimer's and Parkinson's diseases
DNA damage is the prime activator of the enzyme poly (ADP-ribose) polymerase1 (PARP-1)
whose overactivation has been proven to be associated with the pathogenesis of numerous …
whose overactivation has been proven to be associated with the pathogenesis of numerous …
Beyond DNA repair: additional functions of PARP-1 in cancer
AN Weaver, ES Yang - Frontiers in oncology, 2013 - frontiersin.org
Poly (ADP-ribose) polymerases (PARPs) are DNA-dependent nuclear enzymes that transfer
negatively charged ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide …
negatively charged ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide …
PARP1: liaison of chromatin remodeling and transcription
W Zong, Y Gong, W Sun, T Li, ZQ Wang - Cancers, 2022 - mdpi.com
Simple Summary Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …
Functional aspects of PARP1 in DNA repair and transcription
Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for
initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus …
initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus …
Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases
Aims Poly (ADP-ribose) polymerase-(PARP)-1 is predominantly triggered by DNA damage.
Overexpression of PARP-1 is known for its association with the pathogenesis of several …
Overexpression of PARP-1 is known for its association with the pathogenesis of several …
The role of PARPs in inflammation—and metabolic—related diseases: molecular mechanisms and beyond
Y Ke, C Wang, J Zhang, X Zhong, R Wang, X Zeng… - Cells, 2019 - mdpi.com
Poly (ADP-ribosyl) ation (PARylation) is an essential post-translational modification
catalyzed by poly (ADP-ribose) polymerase (PARP) enzymes. Poly (ADP-ribose) …
catalyzed by poly (ADP-ribose) polymerase (PARP) enzymes. Poly (ADP-ribose) …