TRPC1 contributes to endotoxemia-induced myocardial dysfunction via mediating myocardial apoptosis and autophagy
W Tian, SY Liu, M Zhang, JR Meng, N Tang… - Pharmacological …, 2022 - Elsevier
Cardiac dysfunction is a vital complication of endotoxemia (ETM) with limited therapeutic
options. Transient receptor potential canonical channel (TRPC) 1 was involved in various …
options. Transient receptor potential canonical channel (TRPC) 1 was involved in various …
Epigenetic association study uncovered H3K27 acetylation enhancers and dysregulated genes in high-fat-diet-induced nonalcoholic fatty liver disease in rats
J Ma, D You, S Chen, N Fang, X Yi, Y Wang, X Lu… - …, 2022 - Taylor & Francis
Aim: To evaluate the regulatory landscape underlying the active enhancer marked by
H3K27ac in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) in rats …
H3K27ac in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) in rats …
Sirtuin 1 activator alleviated lethal inflammatory injury via promotion of autophagic degradation of pyruvate kinase M2
S Zhao, Y Sun, X Wu, Y Yang, K Fan, K Hu… - Frontiers in …, 2023 - frontiersin.org
Upregulation of pyruvate kinase M2 (PKM2) is critical for the orchestration of metabolism
and inflammation in critical illness, while autophagic degradation is a recently revealed …
and inflammation in critical illness, while autophagic degradation is a recently revealed …
Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota …
Abstract Purpose of Review The study aims to capture the history and lineage of
hypertension researchers from the University of Toledo in Ohio and showcase their …
hypertension researchers from the University of Toledo in Ohio and showcase their …
Biallelic HMGXB4 loss-of-function variant causes intellectual disability, developmental delay, and dysmorphic features
F Al Mutairi, F Joueidi, M Alshalan, E Aloyouni… - Heliyon, 2024 - cell.com
Background HMGXB4 (additionally known as HMG2L1) is a non-histone DNA-binding
protein that contains a single HMG-box domain. HMGXB4 was originally described in …
protein that contains a single HMG-box domain. HMGXB4 was originally described in …
[HTML][HTML] Role of tumor endothelial marker 1 (Endosialin/CD248) lectin-like domain in lipopolysaccharide-induced macrophage activation and sepsis in mice
TL Cheng, YS Lin, YK Hong, CY Ma, HW Tsai… - Translational …, 2021 - Elsevier
Deleterious hyper-inflammation resulting from macrophage activation may aggravate sepsis
and lead to lethality. Tumor endothelial marker 1 (TEM1), a type I transmembrane …
and lead to lethality. Tumor endothelial marker 1 (TEM1), a type I transmembrane …
HMGXB4 Targets Sleeping Beauty Transposition to Germinal Stem Cells
Transposons are parasitic genetic elements that frequently hijack vital cellular processes of
their host. HMGXB4 is a known Wnt signaling-regulating HMG-box protein, previously …
their host. HMGXB4 is a known Wnt signaling-regulating HMG-box protein, previously …
A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo
L Wang, X He, G Hu, J Liu, X Kang, L Yu… - Physiological …, 2024 - Wiley Online Library
HMG (high mobility group) proteins are a diverse family of nonhistone chromosomal proteins
that interact with DNA and a wide range of transcriptional regulators to regulate the structural …
that interact with DNA and a wide range of transcriptional regulators to regulate the structural …