The biomolecules inside or near cells form a complex interacting system. Cellular
phenotypes and behaviors arise from the totality of interactions among the components of …

A central goal of systems biology is the construction of predictive models of bio-molecular
networks. Cellular networks of moderate size have been modeled successfully in a …

Background The understanding of biological networks is a fundamental issue in
computational biology. When analyzing topological properties of networks, one often tends …

Given the complexity and interactive nature of biological systems, constructing informative
and coherent network models of these systems and subsequently developing efficient …

Engineering microbes for the production of valuable natural products is often hindered by
the regulation of native competing metabolic networks in host. This is particularly evident in …

Saccharomyces cerevisiae is an important platform organism for the synthesis of a great
number of natural products. However, the assembly of controllable and genetically stable …

Is evolution predictable at the molecular level? The ambitious goal to answer this question
requires an understanding of the mutational effects that govern the complex relationship …

Extension of the substrate range is among one of the metabolic engineering goals for
microorganisms used in biotechnological processes because it enables the use of a wide …

Biological signalling networks allow living organisms to issue an integrated response to
current conditions and make limited predictions about future environmental changes. Small …

The yeast Saccharomyces cerevisiae employs different conserved signaling pathways to
adapt to altered availability of nutrient and energy sources. Crosstalk between the pathways …