Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate
hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic …

Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

All members of the Borrelia genus that have been examined harbour a linear chromosome
that is about 900 kbp in length, as well as a plethora of both linear and circular plasmids in …

Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory
pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting …

Infection with Borrelia burgdorferi often triggers pathophysiologic perturbations that are
further augmented by the inflammatory responses of the host, resulting in the severe clinical …

Lyme disease, caused by Borrelia burgdorferi, B. afzelii and B. garinii, is a chronic, multi-
systemic infection and the spectrum of tissues affected can vary with the Lyme disease …

Borrelia burgdorferi is the causative agent of Lyme disease in the US, with at least 25,000
cases reported to the CDC each year. B. burgdorferi is thought to enter and exit the …

Almost all spirochetes in the genus Borrelia (sensu lato) naturally contain multiple variants of
closely related prophages. In the Lyme disease borreliae, these prophages are maintained …

ABSTRACT Introduction Transmitted by ticks, Lyme disease is the most common vector-
borne disease in the Northern hemisphere. Despite the geographical expansion of human …

As opposed to pathogens passively circulating in the body fluids of their host, pathogenic
species within the Spirochetes phylum are able to actively coordinate their movement in the …